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Isoguvacine hydrochloride

CAS No. 68547-97-7

Isoguvacine hydrochloride ( 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride )

产品货号. M26261 CAS No. 68547-97-7

Isoguvacine Hydrochloride 是一种 GABA 受体激动剂。 Isoguvacine Hydrochloride 与大鼠突触皮质膜结合并激活 α1β2γ2S、α2β2γ2S、α3β2γ2S、α5β2γ2S 和 ρ1 亚基 GABAA 受体。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
25MG ¥462 有现货
50MG ¥778 有现货
100MG ¥1191 有现货
500MG ¥2989 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Isoguvacine hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Isoguvacine Hydrochloride 是一种 GABA 受体激动剂。 Isoguvacine Hydrochloride 与大鼠突触皮质膜结合并激活 α1β2γ2S、α2β2γ2S、α3β2γ2S、α5β2γ2S 和 ρ1 亚基 GABAA 受体。
  • 产品描述
    Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.(In Vitro):Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus.
  • 体外实验
    Isoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus. Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA. Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures. Isoguvacine inhibits the low magnesium induced seizure like events dose dependently.
  • 体内实验
    ——
  • 同义词
    1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    NR2B-NMDA
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    68547-97-7
  • 分子量
    163.6
  • 分子式
    C6H10ClNO2
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : 100 mg/mL (611.25 mM)
  • SMILES
    Cl.OC(=O)C1=CCNCC1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.
产品手册
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