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Isoguvacine hydrochloride
CAS No. 68547-97-7
Isoguvacine hydrochloride ( 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride )
产品货号. M26261 CAS No. 68547-97-7
Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥462 | 有现货 |
|
| 50MG | ￥778 | 有现货 |
|
| 100MG | ￥1191 | 有现货 |
|
| 500MG | ￥2989 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Isoguvacine hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
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产品描述Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.(In Vitro):Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus.
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同义词1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
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通路Others
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靶点Other Targets
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受体NR2B-NMDA
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研究领域——
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适应症——
化学信息
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CAS Number68547-97-7
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分子量163.6
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分子式C6H10ClNO2
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.OC(=O)C1=CCNCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.
产品手册
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